Anti-Inflammatory and Hematological Effects of Tithonia diversifolia Extract in Streptozotocin-Induced Diabetic Rats
Keywords:
Tithonia diversifolia, diabetes mellitus, streptozotocin-induced, diabetic rat, hematological profile, anti-inflammatoryAbstract
Background: Diabetes mellitus is a significant global health issue with increasing prevalence worldwide.
Objectives: This study aimed to investigate the potential of Tithonia diversifolia extract (TE) in modulating tumor necrosis factor-alpha (TNF-α) levels in streptozotocin-induced diabetic rats.
Methods: Twenty-four rats were divided into four groups: control (P0), diabetic induction (P1), diabetic induction + TE (P2), and diabetic induction + quercetin (P3). Diabetes was induced by a single-dose injection of streptozotocin (60 mg/kg), and TE was administered orally for 7 days. On the 8th day, blood samples were collected to assess TNF-α and hematological profiles, while kidneys were analyzed histopathologically. Data were analyzed using ANOVA and Duncan's test (p<0.05).
Results: The P2 and P3 groups showed significant improvements in hematological profiles, including decreased leukocytes, hemoglobin, lymphocytes, and neutrophils, along with significantly lower IL-35 and TNF-α levels.
Conclusion: TE treatment demonstrated promising effects in reducing inflammatory markers and restoring hematological parameters in diabetic rats, indicating its potential as a therapeutic agent for diabetes management.
