Development of Functionalized Bacterial Cellulose Wound Dressings Using Bio-based Resources

Abstract

Bacterial nanocellulose (BNC) offers superior purity and mechanical properties compared to plant-based cellulose, leading to its wide applications, but its commercial production remains expensive. This research focuses on the valorization of low-grade Cilembu sweet potato as a low-cost substrate for SCOBY (Symbiotic Culture of Bacteria and Yeast) to produce BNC as a raw material for hydrogel synthesis. The process involves producing BNC, performing TEMPO oxidation, and crosslinking with alginate to create a robust hydrogel structure, which is then further functionalized with silver nanoparticles for wound-dressing applications. BNC evaluation involves structural morphology, crystallinity, and functional group analysis. Evaluation of hydrogels involves functional traits such as swelling behavior, antimicrobial activity, and morphology. By integrating biotechnology with local agricultural valorization, this research lays the foundation for sustainable, high-performance biomaterial innovation.