Rodent Models in Cancer Research and Therapy: A One-Health Perspective

This title will be presented on Friday, December 15, 2023 at 08.00-08.15 GMT+7

Abstract

This title will be presented on Friday, December 15, 2023 at 08.00-08.15 GMT+7

Cancer has been the number 1 leading cause of death in Canada. Numerous studies have been conducted and published to understand the disease's nature better, reduce the incidence rate, and increase the survival rate. This article evaluates the success and translational impact of rodent models in cancer research, focusing on the contribution to patient therapy within the One-Health framework. Rodents, particularly mice and rats, have long served as indispensable tools in unravelling the complexities of cancer biology and testing therapeutic interventions. This review examines the strengths and limitations of rodent models. As well as clarifying their role in advancing our understanding of cancer mechanisms and facilitating the development of novel therapeutic strategies. By integrating insights from oncology, comparative biology and translational medicine, this review provides a nuanced understanding of the role of rodent models in bridging the gap between bench and bedside. Ethical considerations regarding animal use in cancer research are also addressed, highlighting the importance of responsible experimental design. This article aims to inform about the specific contributions of rodent models concerning the One-Health paradigm. The analysis presented in this review serves as a guide to optimize rodent model utilization in cancer research for advancing both animal and human health outcomes in this unique Canadian context.