The potential of bromelain enzyme as a safe anthelmintic and minimume residues for livestock commodities

This title has been presented on Thursday, December 14, 2023 at 14.30-14.40 GMT+7.

Abstract

This title has been presented on Thursday, December 14, 2023 at 14.30-14.40 GMT+7.

Livestock commodities are very important as a source milk, meat and eggs are food products of of animal protein source for the Indonesian people. Food production from farm animals will produce optimal results if the animals are healthy and free from disease. Worm infections are an infectious disease problem in livestock that can reduce production and the quality of animal health and cause hemorrhagic lesions in the intestinal mucosal layer during migration in the tissue phase and blockages often occur if the number of worms is so large that the food absorption process is disrupted. The use of anthelmintics is an effort to control worms which can generally be divided into two objectives, namely therapeutic objectives and preventive objectives. The use of anthelmintics requires attention to the incidence of target worm resistance to the drugs used. This is important because the incidence of anthelmintic resistance is a topic and is a problem of concern throughout the world. The use of it also needs to consider residues in food products of animal origin. Bromelain is a proteolytic sulphihydryl fraction. Other components are peroxide, acid phosphatase and several protease inhibitors. The bromelain enzyme is a proteolytic enzyme. This enzyme is known to work as a catalyst in the reaction of breaking protein molecules into peptide bonds and breaking them down into muscle fibers and cells. This bromelain enzyme is thought to play an important role in the antihelminthic effect. In silico molecular docking analysis using USF Chimera software shows that bromelain has anthelmintic potential which works as a destroyer of the cuticular tegument of parasitic walls and is able to bind to astekolin in nematode worms. Bromelain is a natural enzyme in pineapple and can be digested by livestock and causes minimal toxicity and residue. Bromelain can be used as an anthelmintic compound in the future that is safe and free of residue in foods of animal origin.