In Silico Study of Avocado Leaves (Persea americana Mill.) as Inhibitor of Calcium Oxalate Urolithiasis

This title will be presented on Friday, December 15, 2023 at 08.45-08.55 GMT+7

Abstract

This title will be presented on Friday, December 15, 2023 at 08.45-08.55 GMT+7

Urolithiasis, also known as urinary stones, are a disorder where large crystals grow in the urinary tract; these stones are primarily made of calcium oxalate. Improper handling of renal stones can lead to a number of systemic illnesses, including renal failure. The objective of this research is to determine the active components of avocado (Persea americana Mill.) leaves as potential anti-urolithiasis medication candidates by evaluating the potency of their molecular interactions and inhibition potency using the in silico process of molecular docking. Hiperoxaluria is caused by oxalate, which is produced when glycolate oxidase as enzyme that synthesizes oxalate, could inhibited by the majority of the active chemicals in avocados leaves. The result showed oxoassoanine (ΔG -8.2 kcal/mol with Ki 0.961 µM) as one of the active compound exhibits the best potency as glycolate oxidase enzyme inhibitor.