Efficacy of Powdered Young Coconut Drink on Improving Liver and Kidney Function of Streptozotocin-Induced Diabetic Rats

This paper was not presented at the conference.

Abstract

This paper was not presented at the conference.

Diabetes mellitus (DM) can lead to serious vascular complications if left untreated. Powdered young coconut drink (PYCD) shows promise as a potential DM management option.

Objective: This study aimed to assess PYCD's protective role in the liver and kidneys of streptozotocin (STZ)-induced diabetic rats.

Methods: Thirty healthy male Sprague-Dawley rats were divided into five groups: normal control (NC), diabetic control (DC), and diabetic rats treated with glibenclamide at 0.6 mg/kg (DG), PYCD at 3500 mg/kg (DPC3.5), and PYCD at 7000 mg/kg (DPC7). Diabetes was induced by multiple intraperitoneal low-dose injections of STZ (50 mg/kg body weight). The protective effects of PYCD were evaluated through biochemical parameters and histopathological assessments of liver and kidney tissues.

Results: DC rats showed significant increases in AST, ALP, total bilirubin, and direct bilirubin levels, with a trend towards increased ALT. Treatment with PYCD and glibenclamide improved these parameters, particularly in the DPC3.5 group. Histopathological analysis revealed no degenerative changes in liver and kidney tissues across all treatment groups, indicating PYCD's protective effects on these organs in diabetic rats.

Conclusion: In conclusion, PYCD demonstrated liver and kidney protection in diabetic rats comparable to glibenclamide, suggesting its potential as an alternative DM management option.