Advanced Synthesis and Fabrications of Tissue Engineering Scaffolds

This title will be presented on Friday, December 15, 2023 at 13.00-13.15 GMT+7.

Abstract

This title will be presented on Friday, December 15, 2023 at 13.00-13.15 GMT+7.

Tissues or organ damage are major health problems worldwide which are due to trauma, disease or congenital abnormalities. Along with morbidity and mortality there is huge cost associated with these types of health care services. There are several treatment options like transplantation, artificial prostheses, mechanical devices, surgery and drug therapy. If there is major damage to tissue or organ, these procedures do not provide long term recovery and cure. In order to address this issue, tissue engineering is a solution as in this case natural, synthetic or semi-synthetic tissue or organ can be implanted to restore the function. This new paradigm requires scaffolds that balance temporary mechanical function with mass transport to aid biological delivery and tissue regeneration. The functional characteristics of scaffolds include the optimization of porosity, wet ability, biocompatibility, surface topology and mechanical property to mimic the ECM function. The scaffold can be designed and fabricated by freeze drying, porogen salt leaching, thermally induced phase separation, emulsion polymerization, electro spinning and 3D printing. Hence, the goal of this presentation is to describe the various methods for 3-D scaffolds fabrication and then integrate it with different bioactive materials in order to improve their mechanical, chemical and biological properties. Hence, scaffolds will able to provide the proper microenvironment for tissue-scaffold interaction for tissue engineering applications, with a focus on reported clinical and economic outcomes.