Milk metabolites in relation with metabolomics: Perspective from scientometric analysis for trends and future: Will be presented at Friday, 23 May 2025, 10.30 (GMT +7)

Widaningrum Widaningrum; Fatim Illaningtyas; Waryat Waryat; Anna Sulistyaningrum; S Joni  Munarso; Sri Widowati; Arief Arianto; Retno Dumilah Esti Widjayanti; Widya  Puspantari; Windu Negara

Authors

Widaningrum Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN) Author https://orcid.org/0000-0001-7070-0465
Fatim Illaningtyas Research Center Sustainable Production System and Life Cycle Assessment, National Research and Innovation Agency Author
Waryat Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN) Author
Anna Sulistyaningrum Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN) Author https://orcid.org/0000-0001-8185-3096
S Joni Munarso Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN) Author https://orcid.org/0000-0001-8832-0364
Sri Widowati Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN) Author https://orcid.org/0000-0001-8016-0810
Arief Arianto Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN) Author https://orcid.org/0000-0003-4617-9037
Retno Dumilah Esti Widjayanti Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN) Author https://orcid.org/0000-0001-8032-6331
Widya Puspantari Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN) Author https://orcid.org/0000-0001-5102-3139
Windu Negara 2Research Center for Animal Husbandry, National Research and Innovation Agency, Cibinong, Bogor, 16911, Indonesia Author https://orcid.org/0000-0002-9822-9385

Keywords:

Biomarker, cow milk, milk metabolomic

Abstract

The composition and characteristics of milk change over the course of lactation. Metabolomics assesses milk quality, cow health, feeding systems, and potential adulteration. This review aimed to map the metabolic profile of fresh cow's milk. The data were collected from Scopus (2005-2025) using keywords: milk metabolomic, lactation stage, cow feed, location, cattle, bovine, cow’s milk, and goat’s milk. A total of 947 documents were obtained using R-Studio (Biblioshiny) and VOSviewer. Documents dominated by the articles (87.01%), followed by reviews (9.4%), book chapters, conference papers, and books. The highest number of publications (191) occurred in 2024. The top five Journals were Journal of Dairy Science, Animals, Food Chemistry, Food Research International, and Journal of Agricultural and Food Chemistry. The most productive countries were China, The USA, Italy, and Spain. Highly cited global and local documents were authored by Shabat et al. (2016) and Scano et al. (2014), respectively. Most of the analysis used NMR, GC-MS, and LC-MS. Milk metabolites are influenced by cow’s metabolism pathway in each lactation stage, feeds, and genetics. Choline, glycerophosphocoline, and glutamic acid were found as biomarkers for milk coagulation. Further research is needed to explore the milk nutrition, processing, quality, and safety of the milk products.

Author Biographies

Widaningrum, Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)

Researcher at Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)
Fatim Illaningtyas, Research Center Sustainable Production System and Life Cycle Assessment, National Research and Innovation Agency

Researcher at Research Center Sustainable Production System and Life Cycle Assessment, National Research and Innovation Agency, Indonesia
Waryat, Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)

Researcher at Research Center for Agroindustry, National Research and Innovation Agency, Indonesia
Anna Sulistyaningrum, Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)

Researcher at Research Center for Agroindustry, National Research and Innovation Agency, Indonesia
S Joni Munarso, Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)

Professor at Research Center for Agroindustry, National Research and Innovation Agency, Indonesia
Sri Widowati, Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)

Professor at Research Center for Agroindustry, National Research and Innovation Agency, Indonesia
Arief Arianto, Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)

Researcher at Research Center for Agroindustry, National Research and Innovation Agency, Indonesia
Retno Dumilah Esti Widjayanti, Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)

Researcher at Research Center for Agroindustry, National Research and Innovation Agency, Indonesia
Widya Puspantari, Research Center for Agroindustry, Research Organization for Agriculture and Food, National Research and Innovation Agency (BRIN)

Researcher at Research Center for Agroindustry, National Research and Innovation Agency, Indonesia
Windu Negara, 2Research Center for Animal Husbandry, National Research and Innovation Agency, Cibinong, Bogor, 16911, Indonesia

Researcher at Research Center for Animal Husbandry, National Research and Innovation Agency, Indonesia