Kidney cell degeneration in high cholesterol-feeding rats treated with a combination of black glutinous rice and dadih: histology perspective
This title will be presented on Friday, December 15, 2023 at 13.35-13.45 GMT+7
Abstract
This title will be presented on Friday, December 15, 2023 at 13.35-13.45 GMT+7
Hypercholesterolemia can be harmful to cells including kidney cells. Fermented buffalo milk, “dadih” and black glutinous rice are believed to be able to prevent hypercholesterolemia. This study aims to analyze and identify histological changes in the kidneys of high cholesterol-feeding rats treated with dadih, and black glutinous rice. Rats were divided into 3 treatment groups:(A) as the negative control group given distilled water, (B) as the hypercholesterolemia group given 1% cholesterol, and (C) as the hypercholesterolemia prevention group given 1% cholesterol, black glutinous rice, and dadih. All rats were treated for 35 days. Kidneys were collected by necropsy procedure on day 36. Kidney tissue was then made a paraffin method preparation for histology with hematoxylin-eosin staining. The results showed hydropic degeneration of renal tubules in all treatment groups with the highest percentage being in the hypercholesterol group (B) (P<0.05). The percentage of degeneration in the group treated with dadih and black glutinous rice (C) was the same as the negative control (A) (P>0.05). In the hypercholesterolemia group (B), necrosis and congestion were found while in other groups were not. Giving black glutinous rice and dadih as prevention of hypercholesterolemia is able to prevent damage to the kidney organs significantly.
