Assessment of antidiabetic activity of Zingiber officinale and Cajanus cajan leaf extracts in the alloxan-diabetic rats

This title has been presented on Friday, December 14, 2023 at 11.55-12.05 GMT+7.

Abstract

This title has been presented on Friday, December 14, 2023 at 11.55-12.05 GMT+7.

Diabetes mellitus is a metabolic disease characterized by inappropriately elevated blood glucose levels (hyperglycemia). Hyperglycemia leads to oxidative stress condition that promotes some complications, both microangipathy and macroangipathy impairments.  This study aims to assess the antidiabetic activity of combined extracts of C. cajan leaf and Z. officinale in alloxan-diabetic rats.  This study used 25 male Sprague Dawley rats.  They were then divided into five groups; negative control group (NC), positive control group (PC), DM treated with glibenclamide (G), DM treated with combination 300 mg/kg BW of pigeon pea leaf extract, and 60 mg/kg BW of Z. officinale extract (A), DM treated with combination 300 mg/kg BW of pigeon pea leaves extract and 125 mg/kg BW of Z. officinale extract (B). 110 mg/kg BW alloxan was used to induce diabetic conditions in rats.  All treatments were conducted for 28 days. The A group of combination extracts showed the best results in parameters of antidiabetic activity; hypoglycemic activity, increased significantly body weight, insulin level, and the number of beta cells of diabetic rats.  This study suggested that the combination of C. cajan leaf and Z. officinale extracts could be used as an antidiabetic agent for producing such functional food or drink for controlling and maintaining blood glucose levels.